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The pharmacokinetic models used in ADME Workbench are based on research resulting from the PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, and described in a series of articles published in the Journal of Pharmaceutical Sciences in 2011. Extension of the models and implementation in ADME Workbench has resulted from an ongoing scientific collaboration between Dr. Patrick Poulin and AEgis Technologies.

For more information about the PhRMA group, visit http://www.phrma.org.

Citations for the series of articles appearing in the Journal of Pharmaceutical Sciences follow:

 

  • Poulin, P., Jones, H. M., Jones, R. D. O., Yates, J. W. T., Gibson, C. R., Chien, J. Y., Ring, B. J., et al. (2011). PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 1: Goals , Properties of the PhRMA Dataset , and Comparison with Literature Datasets, 100(10), 4050–4073. doi:10.1002/jps
  • Jones, R. D. O., Jones, H. M., Rowland, M., Gibson, C. R., Yates, J. W. T., Chien, Y., Ring, B. J., et al. (2011). PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 2: Comparative Assessment of Prediction Methods of Human Volume of Distribution, 100(10), 4074–4089. doi:10.1002/jps
  • Ring, B. J., Chien, J. Y., Adkison, K. K., Jones, H. M., Rowland, M., Jones, D. O., Yates, J. W. T., et al. (2011). PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 3: Comparative Assessement of Prediction Methods of Human Clearance, 100(10), 4090–4110. doi:10.1002/jps
  • Vuppugalla, R., Marathe, P., He, H., Jones, R. D. O., Yates, J. W. T., Jones, H. M., Gibson, C. R., et al. (2011). PHRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 4: Prediction of Plasma Concentration – Time Profiles in Human from In Vivo Preclinical Data by Using the Wajima Approach, 100(10), 4111–4126. doi:10.1002/jps
  • Poulin, P., Jones, R. D. O., Jones, H. M., Gibson, C. R., Rowland, M., Chien, J. Y., Ring, B. J., et al. (2011). PHRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 5: Prediction of Plasma Concentration – Time Profiles in Human by Using the Physiologically-Based Pharmacokinetic Modeling Approach, 100(10), 4127–4157. doi:10.1002/jps

 

Following several months of product/market analysis and careful leadership consideration, effective November 24, 2015
The AEgis Technologies Group will cease further development all variants of our ACSL/X and ADME products.
The last day that these products, and annual maintenance were available for purchase was November 24, 2015.
The Sale of New Licenses has Ended as of November 24, 2015.
All purchases made until said date will be honored in their entirety. We will also be offering for purchase a ‘forever’ license, and are open to discussion of source code purchases. Please contact Jtuck@aegistg.com in regards to any of these matters.

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