References

The pharmacokinetic models used in ADME Workbench are based on research resulting from the PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, and described in a series of articles published in the Journal of Pharmaceutical Sciences in 2011. Extension of the models and implementation in ADME Workbench has resulted from an ongoing scientific collaboration between Dr. Patrick Poulin and AEgis Technologies.

For more information about the PhRMA group, visit http://www.phrma.org.

Citations for the series of articles appearing in the Journal of Pharmaceutical Sciences follow:

 

  • Poulin, P., Jones, H. M., Jones, R. D. O., Yates, J. W. T., Gibson, C. R., Chien, J. Y., Ring, B. J., et al. (2011). PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 1: Goals , Properties of the PhRMA Dataset , and Comparison with Literature Datasets, 100(10), 4050–4073. doi:10.1002/jps
  • Jones, R. D. O., Jones, H. M., Rowland, M., Gibson, C. R., Yates, J. W. T., Chien, Y., Ring, B. J., et al. (2011). PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 2: Comparative Assessment of Prediction Methods of Human Volume of Distribution, 100(10), 4074–4089. doi:10.1002/jps
  • Ring, B. J., Chien, J. Y., Adkison, K. K., Jones, H. M., Rowland, M., Jones, D. O., Yates, J. W. T., et al. (2011). PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 3: Comparative Assessement of Prediction Methods of Human Clearance, 100(10), 4090–4110. doi:10.1002/jps
  • Vuppugalla, R., Marathe, P., He, H., Jones, R. D. O., Yates, J. W. T., Jones, H. M., Gibson, C. R., et al. (2011). PHRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 4: Prediction of Plasma Concentration – Time Profiles in Human from In Vivo Preclinical Data by Using the Wajima Approach, 100(10), 4111–4126. doi:10.1002/jps
  • Poulin, P., Jones, R. D. O., Jones, H. M., Gibson, C. R., Rowland, M., Chien, J. Y., Ring, B. J., et al. (2011). PHRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics , Part 5: Prediction of Plasma Concentration – Time Profiles in Human by Using the Physiologically-Based Pharmacokinetic Modeling Approach, 100(10), 4127–4157. doi:10.1002/jps

 

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