Press Releases

AEgis Technologies To Show Latest ADME WorkBench Features at 2014 Society of Toxicology Conference

Huntsville, Alabama (March 19, 2014) – The AEgis Technologies Group, Inc., a leading provider of modeling and simulation software, training and consulting services to the pharmaceutical, biotech, toxicology and risk assessment communities, will present the latest additions to ADME WorkBench at the 2014 Society of Toxicology Conference in Phoenix, Arizona on March 23-27, 2014.

ADME WorkBench is a versatile software application providing flexible, robust pharmacokinetic modeling by integrating state-of-the-art absorption, distribution, metabolism and excretion methods. Designed for research applications in pharmacology and toxicology, ADME WorkBench supports pharmacokinetic prediction from available in vitro and/or in vivo data for drugs and environmental chemicals. The ADME WorkBench user interface offers a highly optimized workflow for predictive pharmacokinetics, while allowing ample flexibility to adapt to specific research needs.  The pharmacokinetic models used in ADME WorkBench are based on research resulting from the PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, and described in a series of articles published in the Journal of Pharmaceutical Sciences in 2011.

Recently added ADME Workbench capabilities include:

  • Support for intestinal influx and efflux transporters
  • Inclusion of gut metabolism
  • Support for calibration of human Peff prediction models based on Caco2 assay data
  • Support for repeated dosing scenarios
  • User interface and performance improvements

Stop by booth 1018 to learn more about ADME WorkBench, acslX, and AEgis’ consulting and training services.

About The AEgis Technologies Group Inc.

AEgis Technologies is a privately held small business headquartered in Huntsville, Alabama, USA, that provides advanced technology and expert consulting services to industries throughout the world.  AEgis specializes in modeling & simulation (M&S) and micro/nanoscale technology development.  The company’s M&S products and services include simulation software and training simulators; geospatial databases; 3D models; war fighter exercise support; systems engineering and analysis; verification, validation, and accreditation (VV&A); test and evaluation support; Hardware-in-the-Loop (HWIL) and Man-in-the-Loop (MIL) simulation.   AEgis excels in advancing cutting edge micro and nanoscale technologies with applications ranging from defense to energy to biotechnology.

Recently, AEgis was nominated as a 2013 Huntsville-Madison County Chamber of Commerce “Best Places to Work” and its President & CEO, Steve Hill, was awarded the 2012 Russell G. Brown Executive Leadership Award for excellence in leadership and entrepreneurship.

AEgis has enjoyed steady growth with revenues increasing to $65+ million in sales and employment of 325+ professionals. AEgis has been instrumental in the acceptance of M&S as a profession, as a graduate program of study and in the creation of an M&S standards and professional certification across the international M&S professional community-of-practice. Since its founding in 1989, AEgis is committed to honesty and integrity and has received the Better Business Bureau’s Torch Ethics Award for its honorable business practices. The company’s highly skilled work force is dedicated to building lasting relationships and providing superior products and services to our customers.

ADME WorkBench and acslX are a trademarks of The AEgis Technologies Group, Inc.

Find us at http://www.admewb.com or http://www.acslx.com and follow us on Twitter @admewb

Older Press Releases

AEgis Technologies Announces Official Launch of ADME WorkBench Software for Pharmacokinetics Prediction

Huntsville, Alabama (PRWEB) September 16, 2013 – The AEgis Technologies Group, Inc., is pleased to announce the release of ADME WorkBench, a new software product for pharmacokinetic prediction. Newly available in 2013, ADME Workbench is a versatile software application providing flexible, robust pharmacokinetic modeling by integrating state-of-the-art absorption, distribution, metabolism and excretion methods. Designed for research applications in pharmacology and toxicology, ADME WorkBench supports pharmacokinetic prediction from available in vitro and/or in vivo data for drugs and environmental chemicals. The ADME WorkBench user interface offers a highly optimized workflow for predictive pharmacokinetics, while allowing ample flexibility to adapt to specific research needs. The pharmacokinetic models used in ADME WorkBench are based on research resulting from the PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, and described in a series of articles published in the Journal of Pharmaceutical Sciences in 2011. Extension of the models and implementation in ADME WorkBench has resulted from an ongoing scientific collaboration between Dr. Patrick Poulin and AEgis Technologies.

“We are excited to provide drug discovery and toxicology scientists a powerful new platform implementing a wide variety of predictive PK techniques, and which doesn’t depend on black-box proprietary models,” said Director of acslX Product Development Conrad Housand. “This release is the culmination of over two years of collaboration, development and testing, and we look forward to incorporating even more capabilities in the coming months.”

Current ADME Workbench capabilities include:

  • Support for several state-of-the-art PK prediction techniques, including whole-body and lumped physiologically-based pharmacokinetic (PBPK) models, and allometry based on the Wajima approach
  • PBPK models which include advanced multi-compartment GI uptake models, support for both linear and nonlinear kinetics, and an advanced liver model
  • Support for end-user customization of any of the provided PBPK models
  • A choice of prediction methods depending on availability of preclinical data determined either in vitro and/or in vivo in single or multiple species
  • Ability to integrate values of ADME parameters predicted from a broad range of methods
  • Ability to simulate a single compound or multiple compounds in batch mode
  • Simulation of tissue concentration at the macro level (whole organ) and micro level (cell, interstitial fluid) either for the bound or unbound drug condition

About The AEgis Technologies Group

AEgis Technologies is a privately held small business headquartered in Huntsville, Alabama, USA, that provides advanced technology and expert consulting services to industries throughout the world. AEgis specializes in modeling & simulation (M&S) and micro/nanoscale technology development. The company’s M&S products and services include software for the pharmaceutical/risk assessment, industrial process, automotive, and military/aerospace markets. AEgis’ Nanogenesis Division excels in advancing cutting edge micro and nanoscale technologies from concept to deployment with applications ranging from defense to energy to biotechnology.

AEgis has enjoyed steady growth with revenues increasing to $65 million in sales and employment of 325+ professionals. AEgis has been instrumental in the acceptance of M&S as a profession, as a graduate program of study among many colleges and universities and in the creation of an M&S standards and professional certification across the international M&S professional community-of-practice. Since its founding in 1989, AEgis is committed to honesty and integrity and was recognized for its honorable business practices by receiving the Better Business Bureau’s Torch Ethics Award. The company’s highly skilled work force is dedicated to building lasting relationships and providing superior products and services to our customers.

AEgis corporate headquarters are located at 410 Jan Davis Drive, Huntsville, AL 35806; Tel: 256-922-0802; Fax: 256-922-0904; Web: http://www.acslx.com and http://www.admewb.com

Follow us on Twitter @admewb

acslX and ADME WorkBench are a trademarks of The AEgis Technologies Group, Inc.

Read the full story at http://www.prweb.com/releases/2013/9/prweb11109917.htm

 

Nanogenesis to Introduce ADME WorkBench at Annual Society of Toxicology Conference In San Antonio on March 10-14, 2013 February 23, 2013

Huntsville, Alabama – February 23, 2013 Nanogenesis, a Division of The AEgis Technologies Group, Inc. will present ADME WorkBench, a new addition to the Nanogenesis Life Sciences family of tools for PK/PD/PBPK modeling, computational biology, and risk assessment, at the Annual Society of Toxicology conference in San Antonio, Texas on March 10-14, 2013. Newly available in 2013, ADME WorkBench is a versatile software application providing flexible, robust pharmacokinetic modeling by integrating state-of-the-art absorption, distribution, metabolism and excretion methods. Designed for business and research applications in toxicology and pharmacology, ADME WorkBench supports pharmacokinetic prediction from available in vitro and/or in vivo data for drugs and environmental chemicals. The ADME WorkBench user interface offers a highly optimized workflow for predictive pharmacokinetics, while allowing ample flexibility to adapt to specific research needs. The pharmacokinetic models used in ADME WorkBench are based on research resulting from the PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, and described in a series of articles published in the Journal of Pharmaceutical Sciences in 2011. Extension of the models and implementation in ADME WorkBench has resulted from an ongoing scientific collaboration between Dr. Patrick Poulin and Nanogenesis. “We are excited to provide the toxicology and risk assessment community a powerful new platform which offers scientists a wide variety of predictive PK techniques which doesn’t depend on black-box proprietary models,” said Director of Nanogenesis Life Sciences, Conrad Housand. “This release is the culmination of almost two years of collaboration, development and testing, and we look forward to incorporating even more capabilities in the coming year.”

Current ADME WorkBench capabilities include:

  • Support for several state-of-the-art PK prediction techniques, including whole-body and lumped physiologically-based pharmacokinetic (PBPK) models, and allometry based on the Wajima approach ?
  • PBPK models which include advanced GI uptake models (ACAT), support for both linear and nonlinear kinetics, and an advanced liver model ?
  • Support for end-user customization of any of the provided PBPK models ?
  • A choice of prediction methods depending of the availability of preclinical data either determined in vitro and/or in vivo in single or multiple species ?
  • Ability to integrate values of ADME parameters predicted from a broad range of methods ?
  • Ability to simulate a single compound or multiple compounds in batch mode ?
  • Simulation of tissue concentration at the macro level (whole organ) and micro level (cell, interstitial fluid) either for the bound or unbound drug condition

About AEgis Technologies

AEgis Technologies is a privately held small business headquartered in Huntsville, Alabama, USA, that provides advanced technology and expert consulting services to industries throughout the world. AEgis specializes in modeling & simulation (M&S) and micro/nanoscale technology development. The Nanogenesis Division of AEgis has the mission of delivering innovative nanotechnology solutions that have a positive life-changing impact. This creative group excels in advancing cutting edge technology from concept to deployment with applications ranging from defense to energy to biotech. ADME WorkBench is the latest addition to their Life Sciences family of products. AEgis has enjoyed steady growth with revenues increasing to $60 million in sales and employment of 265+ professionals. AEgis has been instrumental in the acceptance of M&S as a profession, as a graduate program of study among many colleges and universities and in the creation of an M&S standards and professional certification across the international M&S professional community-of-practice. Since its founding in 1989, AEgis is committed to honesty and integrity and was recognized for its honorable business practices by receiving the Better Business Bureau’s Torch Ethics Award. The company’s highly skilled work force is dedicated to building lasting relationships and providing superior products and services to our customers.

AEgis corporate headquarters are located at 410 Jan Davis Drive, Huntsville, AL 35806; Tel: 256-922- 0802; Fax: 256-922-0904; Web: http://www.admewb.com, http://www.nanogenesisgroup.com, and http://www.aegistg.com

Follow us on Twitter @nanogenesis and @AEgisTG. Nanogenesis and ADME WorkBench are trademarks of The AEgis Technologies Group, Inc. ####

 

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